Australian scientists have identified a critical molecular ‘feedback loop‘ that helps initiate and drive neuroblastoma, a cancer of the nervous system in children that is triggered in embryonal nerve cells.
The authors showed in laboratory models of neuroblastoma that the drug could block the very start of this embryonal cancer, paving the way to possible prevention strategies in the future.
New way to Cure neuroblastoma cancer :
The new study, from the Institute, found that the drug known as CBL01371.
- It is used in combination with traditional DNA damaging chemotherapy agents was much more effective than either drug alone because CBL0137 created a ‘synthetic lethal‘ state by preventing the cancer cells from repairing DNA damage induced by chemotherapy, and so ensuring cell death.
Highlights :
- These important findings were published in the international journal Science Translational Medicine.
- Michelle Haber AM and Glenn Marshall AM, respective leaders of the Experimental Therapeutics and Molecular Carcinogenesis laboratories at the Institute, worked on two very different aspects of the study.
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